This is definitely possible, although not required. Most of the migrations we perform specify the same email address at the Source and Destination.
MigrationWiz uses the information you specify on your connector (for example, host name, URL, etc.) in conjunction with email addresses you specify to connect to Source and Destination mailboxes. We do not use MX record information in order to connect to Source and Destination mailboxes.
As long as the email addresses you specify at the Source and Destination match an existing mailbox that can be logged in to, MigrationWiz should be able to connect and migrate data.